Perugu Shyam

Assistant Professor

Department of Biotechnology

National Institute of Technology, Warangal - 506004, Telangana, INDIA

: shyamperugu@nitw.ac.in

: 9948561761

Interests: Bioinformatics, Systems biology, Next Generation Sequencing, Molecular Modeling, Molecular Dynamics & Simulations, Drug Design and Discovery, Machine Learning, Data Science, Bigdata, High Performance Computing (HPC).

 

Education:

 

Ph.D. (Bioinformatics),  University of Hyderabad and Osmania, Hyderabad, Telanagana, India

M.Tech (Bioinformatics), University of Hyderabad, Hyderabad, Telanagana, India

PGDBI (Bioinformatics), Osmania University, Hyderabad, Telanagana, India

 

Experience:

Present:  Assistant Professor,  Department of Biotechnology, National Instituite of Technology, Warangal, Telangana, India.

2013 - 2018:  Scientist-B , ICMR- National Institute of Nutrition, Hyderabad, Telangana, India.

2010-13: Lecturer, School of Information Technology,  Jawaharlal Nehru Technological University, Hyderabad(JNTUH), Hyderabad, Telangana, India.

 

Websites & Databases Developed:

Nutrition Atlas

http://218.248.6.39/nutritionatlas/home.php

 

Count What You Eat

 http://218.248.6.43:8080/CountWhatYouEat/Home.do

 

Foodborne Diseases Surveillance Portal (FBDSP)

http://218.248.6.43:8080/searchnews.jsp

 


 

 

 

 

Course Taught Previously


Courses Handled:

  • Bioinformatics
  • Systemsbiology
  • Machine Learning Methods
  • Molecular Modelling and Simmulations
  • Drug Design and Discovery
  • High Performance Computing(HPC)
  • Genomics and Proteomics
  • Molecular Biology
  • Biostatistics and Computers

Publications

Research Publications: 

1) Srinivas B,  Shyam P, David  KGL.   Regioselective   synthesis of novel 2-((1- Benzyl-1H- 1, 2, 3-triazol- 4-yl) methyl)-5-(2H- chromen-3- yl)-2H- tetrazoles by click reaction, in vitro         antibacterial, antioxidant and molecular docking studies.   Russian Journal of Bioorganic Chemistry, 2018, 44, 2, 244 -251.

2) Sonyanaik Banoth, Shyam P, Sakram Boda. Green Synthesis of Fused Imidazo [1,2- a][1,8]naphthyridine   Derivatives   Catalyzed   by   DABCO   under   Solvent-Free   Solid-State Conditions         and  Their  Biological  Evaluation.  Journal  of  Heterocyclic  Chemistry,  2018.  DOI 10.1002/jhet.3092.

3)  Bhookya  Shankar,  Pochampally Jalapathi,  Balabadra  Saikrishna, Shaym  P, Vijjulatha  Manga. Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5- (3- (1H-benzo[d]           imidazol-2-yl)-4-hydroxybenzyl) benzofuran-2-yl)(phenyl) methanone analogs. Chemistry Central Journal.2018, 12:1. doi.10.1186/s13065-017-0364-3.

4)  Sonyanaik B, Sakram B, Shyam P, Saikrishna B, Vijjulatha M. Design, synthesis, biological evaluation and in silico molecular docking studies of novel benzochromeno [2,3-                                                 d] thiazolopyrimidine derivatives. Res Chem Intermed. 2017; DOI; 10.1007/s11164-017-3201-3.

5)  B. Sakram, B. Sonyanaik, K. Ashok, S. Rambabu, D. Ravi, A. Kurumanna, Shyam P.   Eco- friendly synthesis of 1, 8-naphthyridine 5-aryl-1, 3, 4-oxadiazole derivatives under solvent-free            solidstate   conditions   and   their   antimicrobial   activity.   Res   Chem   Intermed,   2016,  DOI 10.1007/s11164-016-2736-z.

6)  Ismail A, Noolu B, Gogulothu R, Shaym P, Rajanna A, Babu SK. Cytotoxicity and proteasome inhibition by alkaloid extract from Murraya koenigii leaves in breast cancer cells -                                            molecular docking studies. J Med Food. 2016; 19(12):1155-1165.

7)  Sakram B, Sonyanaik B,  Ashok K,  Rambabu S,   Ravi D,  Kurumanna,  Shyam P. Eco-friendly synthesis of 1, 8-naphthyridine 5-aryl-1, 3, 4-oxadiazole derivatives under solvent-free                               solid- state conditions and their antimicrobial activity. Res Chem Intermed. DOI 10.1007/s11164-016-2736-z.

8) Gopinath G, Sankeshi V, Shaym P, Alaparthi MD, Bandaru S, Pasala VK, Chittineni PR, Krupadanam GLD, Sagurthi SR. Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid           conjugates as aldose reductase inhibitors. Eur J Med Chem. 2016; 124:750-762.

9)  Ramakrishna U. V., Shyam P, Sinha S. N., Vakdevi V. Drug-Repositioning of the gallate group from EGCG for the repurposing.  Eur J Pharm Med Res. 2016; 3(7), 253-262.

10)  Sukesh  N  S,  Paritosh  K.  K,  Shyam  P,  RamaKrishna  U  V.  Adefovir  dipivoxil A  possible regimen for the treatment of dengue virus (DENV) infection. Chemometr Intell Lab Syst. 2016;                     155, 120 -127.

11) Ravi M, Chennam KP, Ushaiah B, Eslavath RK, Shaym P, Ajumeera R, Devi ChS. A Study on Spectro-Analytical Aspects, DNA- Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic                Activities, Antibacterial and Docking Properties of 3 - (1 - (6 - methoxybenzo [d] thiazol - 2 - ylimino) ethyl) - 6 - methyl - 3H - pyran - 2, 4 - dione and its Metal Complexes. J Fluoresc.                           2015;  25(5):1279-96.

12) Shyam P,Veerababu N, Manjula B. Green synthesis of silver nanoparticles using leaf extract medicinally potent plant Saraca indica: a novel study. Appl Nanosci.2016; 6, 5, 747-753.

13) Shaym P, Radhikavemula, Vishnu VardhanaRao M.Walnut pedunculagin a probable serm for breast cancer treatment. Int J Pharm Pharm Sci; 7, 1, 2015.

14) Gopinath G, Someswar   RS, Shyam P, Achaiah   G, Krupadanam G. L. Rational design and synthesis of novel 2-substituted-2H- hromen-3-yl)-5-aryl-1Himidazole derivatives as an anti-                    angiogenesis and anti-cancer agent. RSC Adv. 2014; 4, 56489.

15) Ushaiah B, leela DS, Ravi M, Anupama B, Shaym P, Kumari CG. Synthesis, Characterization, Antibacterial, DNA Binding and Cleavage Studies of Mixed Ligand Cu (II), Co (II) Complexes. J              Fluoresc. 2014; 24(6):1687-99.

16) Chandrasai P, Shaym P, Durga B. Deciphering the sequence alignment by Needleman-Wunsch algorithm on to reduce computational time Via High Performance Computing. IJCSMC.                      2014;   3(6), 741-753.

17) Chetan N, Sravani E, Venu R,  Shaym P, Ravindranath, Dinesh Kumar. Role of in-silico COX2 molecular docking bioinformatics tool and in-vivo carrageenan induced various inflammatory              phase in mouse and rat models, in evaluation of anti-inflammatory activity of molecules. Intern Jour of Phar Res Rev. 2014; 3(4):57-65.

18) Tipirisetti NR, Govatati S, Pullari P, Malempati S, Thupurani MK, Shaym P, Guruvaiah P, Rao K L, Digumarti RR, Nallanchakravarthula V, Bhanoori M, Satti V. Mitochondrial Control                             Region Alterations and Breast Cancer Risk: A Study in South Indian Population. PLoS One. 2014; 9(1):e85363.

19) Shyam P, Harika J, Manjula B. SSViewer: Sequence Structure Viewer. International Journal of Innovative Technology and Exploring Engineering. 2013; 3(4), 2278-3075.

20) Padmavathi A.V, Shyam P, Manohar Rao D.  In Silico  Characterization of 14 - 3-3 Protein  Identified  In  Peanut  (ArachisHypogaea  L.)  Under  Drought  Stress.  International

       Journal of Innovative Technology and Exploring Engineering. 2013; 3(4), 2278-3075.

21) Govatati S, Tipirisetti NR, Shaym P, Kodati VL, Deenadayal M, Satti V, Bhanoori M,       ShivajiS.Association  of  Mitochondrial  Genome  Variations  and  Haplogroups  with  Advanced Stage            Endometriosis in Indian Women. PLoS One. 2012;7(7):e40668.

22) Shyam P, Purushottam N,   Shaik SN. ECDB- A database for endometrial cancer. Journal of Computational Intelligence in Bioinformatics (JCIB). 2012; 5, 161-167.

 

 

 

PHDs Supervised

 

Workshops/Conferences

Invited Talks: 

  • India International science Festival (IISF-2016) held in 7th - 11th December 2016 at National Physical Laboratory, Organized by DST, New Delhi.
  •  International conference on Biochemistry, Nutrition & Pharmacy in Human  welfare:  recent  trends  and  future  challenges.  held  between  3rd and 5th   September  2015 organized by Department of Biochemistry, Osmania University, Hyderabad.
  • National Level Workshop on Biostatistics and Its Applications in Biomedical Research, held from March 24th - 28th, 2014 at National Institute of Nutrition, Hyderabad.
  • Three Day National Level Workshop on Recent Trends in Drug Design, 8th - 10th May 2013 at School of Information Technology, Jawaharlal Nehru Technological University Hyderabad.

 

Educational Outreach Activities :

  • National Science Day: Student Scientist Interaction at Nalgonda, Telangana State.
  • State Level Science Fair: Student Scientist Interaction at Warangal, Telangana State.
  • District Level Science Fair: Student Scientist Interaction at Suryapet, Telangana State.
  • District Level Science Fair: Student Scientist Interaction at Miryalaguda, Telangana State.
  • Conducted one day Practical session for school children's at Hyderabad, Telangana State.

 

Professional Trainings Undergone: 

  • GIAN-Immunologicals in Animal and Human Health, held between 04th  and 16th July conducted by School of life sciences, University of Hyderabad, Hyderabad, India. 
  • Parallel programming for engineers and scientists from 10th to 20th  June 2013 conducted by CDAC-Bangalore. 
  • Enterprise Solutions for Web Applications held from 28th May to 8th  June 2012 conducted by CDAC-Hyderaba

 

Conferences/ Workshops Conducted:

 

  • Co-Convener for National Level Workshop on Biostatistics and Its Applications in Biomedical Research, held from March 24th - 28th, 2014 at National Institute of Nutrition, Hyderabad.
  • Convener for a Three Day National Level Workshop on Recent Trends in Drug Design, 8th - 10th May 2013 in School of Information Technology, Jawaharlal Nehru Technological University Hyderabad.
  • Convener for a Two Day National Level Conference on Bioinformatics and its Applications, 5th - 6th October 2012 in School of Information Technology, Jawaharlal Nehru Technological University Hyderabad.

 

Conferences/ Workshops Presented:

  • International Conference: Integrative Biology & Applied Genetics (ICIBAG - 2018) 15th - 17th March, 2018.
  • International Conference on Biochemistry, Nutrition & Pharmacy in Human Welfare:Recent trends and future challenges organized by Department of Biochemistry, Osmania University, Hyderabad, Telangana, India.
  • National Symposium on Current Trends in Biotechnology held in 7th- 8th  December 2013.
  • National Seminar on Recent Trends in Plant Science 22nd - 23rd August, 2014 conducted by Sathavahana University, Karimnagar.
  • National  Seminar  on  Computer  Simulations:  Chemistry  of  Bioactive Molecules held 6th-7th August 2014, Suryapet, Nalgonda.
  • 16th  ADNAT convention conference on Animal Genetics and Genomics held in 16th - 19th December 2012, University of Hyderabad, Hyderabad.

 

 Conferences/ Workshops/ Seminars Participated:

  •   International conference on frontiers in comparative endocrinology and Neurobiology-2014 held in 25th - 28th  November 2014 conducted by Department of Animal Biology, school of Life Sciences, University of Hyderabad-Hyderabad.
  • International Symposium of Inflammatory Bowel Disease held in 22nd - 24th August 2014 conducted by AIG-Hyderaba Hyderabad, India. 
  • 16th ADNAT workshop on Genomics and beyond held in 6th - 16th December 201, Hyderabad, India. 
  • Next-Generation Sequencing-2011 held in 13th - 17th June 2011 conducted by National Institute of Nutrition (NIN), Hyderabad, India. 
  • Privacy and security in online social media conducted by CDAC, Hyderabad, India. 
  • MATLAB and  Simulink  for  engineering  education  conducted  by MATLA, Hyderabad, India. 

 

Memberships in Scientific Societies:

  1. International Conference on Systems Biology (ICSB)
  2. International Association of Engineers (IAENG)
  3. International Association of Computer Science and Information Technology(IACSIT).

 

Projects

 

Awards and Honors

 Achievements and Awards:

Awarded N-PDF fellowship in 2015.

Awarded UGC-BSR meritorious fellowship in 2013.

Awarded GATE fellowship in 2011.

 

 

Additional Responsibility