Dr. V. Kohila

Assistant Professor

Department of Biotechnology

National Institute of Technology, Warangal - 506004, Telangana, INDIA

: v.kohila@nitw.ac.in

: 8332969460

Interests: Gene therapy, Molecular biology, Immunology, Bioinformatics

 Specialization: 

Gene therapy for cancer and rheumatoid arthritis

Education:

  1. PhD, Biotechnology: 2014, IIT Guwahati.
  2. M.Tech, Biotechnology: 2008, WBUT, Kolkata.
  3. B.Tech, Biotechnology: 2006, MEPCO, Anna University, Chennai.

Positions Held:

  1. Assistant Professor, NIT Warangal, September 2013- till date.
  2. Faculty (Adhoc), NIT Warangal, Mar- Aug, 2013.    

Course Taught Previously

 Course Taught Previously:

BT363 - Medical Biotechnology

BT254 - Molecular Biology & Genetics Lab

BT301 - Immunology

BT304 - Immunology Lab

BT101 - Engineering Biology

BT465 - Genomics and Proteomics

BT256 - Molecular Biology Lab

Courses Currently Being Taught:

BT5114 - Molecular Immunology

BT303 - Immunology



 

Publications

Journal Publications:

4. R. Kowshik Aravilli, S. Laveen Vikram, V. Kohila*. The functional impact of alternative splicing and single nucleotide polymorphisms in rheumatoid arthritis. Current Pharmaceutical Biotechnology, 2020 (Published). [Bentham publications]. SCI, IF: 2.097. doi: 10.2174/1389201021666201001142416.

3. R. Kowshik Aravilli, S. Laveen Vikram, V. Kohila*. Phytochemicals as potential antidotes for targeting NF-kappaB in rheumatoid arthritis. 3 biotech, 2017, 7:253. [Springer publications]. SCI, IF: 1.798..

2. Raza MA, V. Kohila, Ghosh SS. Redesigned E. coli cytosine deaminase: a new facet of suicide gene therapy. J Gene Med, 2015, 17, 132-139. [John Wiley & sons Ltd]. SCI, IF: 3.258.

1. V. Kohila, Amit Jaiswal, Siddhartha Sankar Ghosh. Rationally designed Escherichia coli cytosine deaminase mutants with improved specificity towards the prodrug 5-fluorocytosine for potential gene therapy applications. Med. Chem. Commun., 2012, 3, 1316-1322. [RSC publications]. SCI, IF: 2.4.

 

PHDs Supervised

Mr. R. Kowshik Aravilli (Full time scholar) - July 2014 - till date

 

Workshops/Conferences

Conferences/Workshops attended:

8.  R. Kowshik Aravilli, V. Kohila*. Redesigned hGSTM1- an antidote to oxidative stress, Recent Advancements in Biochemical Engineering and Biotechnology, 15-16 March, 2019, IIT BHU, Varanasi.

7. R. Kowshik Aravilli, V. Kohila*. In silico redesigning of hGSTM1 towards suppression of oxidative stress in rheumatoid arthritis, International Conference on Advances in Biotechnology and Biotherapeutics, 8-10 March, 2017, Sathyabama University, Chennai. 

6. V. Kohila*. Solar driven water disinfection by ozonization using phytoplankton: An overview, International Conference on Innovations in Sustainable Water & Waste water Treatment Systems, 21-23 April, 2016, CSIR-NEERI, Pune.

5. V. Kohila*. Restructured Rubisco for enhanced biosequestration of carbon dioxide by effective bioprecipitation of calcium carbonate, International Conference on Recent Trends in Biosciences, [Poster Presentation; Awarded Second Prize]7-9 April 2016, Alagappa University, Karaikudi.

4. R. Kowshik Aravilli, V. Kohila*. In silico modeling of hGSTM1 to suppress inflammation in rheumatoid arthritis, International Conference and Workshop on structure based drug designing and application to infectious diseases, 1-5 February, 2016, HCU, Hyderabad.

3. Asif raza, V. Kohila, Siddhartha Sankar Ghosh. Application of redesigned E. coli cytosine deaminase in the perspective of cancer, 5th International Conference on Stem Cells and Cancer (ICSCC-2014): Proliferation, Differentiation and Apoptosis, 8-11 November, 2014, JNU, New Delhi.

2.  V. Kohila, Siddhartha Sankar Ghosh*. The Emergence of E. coli Uracil PhosphoRibosylTransferase mutants in the prospect of cancer therapeutics: a Bioinformatics Approach, International Symposium on Bioengineering, 2012, IIT Guwahati. 

1. V. Kohila, Amit Jaiswal, Siddhartha Sankar Ghosh*. Redesigning of E. coli cytosine deaminase in the perspective of cancer therapeutics,  3rd International Conference on Stem Cells and Cancer: Proliferation, Differentiation and Apoptosis (ICSCC- 2012), 27-30 October, 2012. [Poster Presentation; Best Poster Award], PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi.

Projects

1. Anti-inflammatory effect of a novel fusion suicide gene bCDS126R-hGST on rheumatoid arthritis, ICMR, 2017-2020.

 PI: Dr. V. Kohila;          Co-PI: Dr. Amit jaiswal, Assistant Professor, IIT Mandi.

2. Cytotoxic and tumor suppressor role of a novel fusion suicide gene bCDF186W-hPFN1 on rheumatoid arthritis, Rs. 39.21 lakhs, DST-SERB, 2018-2021.

 PI: Dr. V. Kohila 

Awards and Honors

 Awards and Honours:

1. Qualified Combined Entrance Examination for Biotechnology (CEEB), 2006, conducted by Jawaharlal Nehru University, New Delhi, India.
2. Qualified Department of Biotechnology Junior Research Fellowship (DBT-JRF), 2008.
3. University rank holder (Second) in M.Tech (2008), WBUT.

4. MHRD fellowship to pursue PhD at IIT Guwahati.

Additional Responsibility

Departmental responsibilities:

Faculty In-charge, III B.Tech Biotechnology from 2015 - May 2018

Departmental Time table In-charge from July  2017 - Dec 2017

Departmental Internet & Telecom In-charge from May 2018  - till date

DAC PG & R Member from May 2018 - till date

Institute Responsibilities:

Ladies hostel warden (Priyadarshini hall) from Nov 2018 - till date

Member, Institute Data Analytics Working Group